Brady, Jennifer J., Chuang, Chen-Hua, Greenside, Peyton G., Rogers, Zoe N., Murray, Christopher W., Caswell, Deborah R., Hartmann, Ursula, Connolly, Andrew J., Sweet-Cordero, E. Alejandro, Kundaje, Anshul ORCID: 0000-0003-3084-2287 and Winslow, Monte M. (2016). An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer Cell, 29 (5). S. 697 - 711. CAMBRIDGE: CELL PRESS. ISSN 1878-3686

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Abstract

The ability of cancer cells to establish lethal metastatic lesions requires the survival and expansion of single cancer cells at distant sites. The factors controlling the clonal growth ability of individual cancer cells remain poorly understood. Here, we show that high expression of the transcription factor ARNTL2 predicts poor lung adenocarcinoma patient outcome. Arntl2 is required for metastatic ability in vivo and clonal growth in cell culture. Arntl2 drives metastatic self-sufficiency by orchestrating the expression of a complex pro-metastatic secretome. We identify Clock as an Arntl2 partner and functionally validate the matricellular protein Smoc2 as a pro-metastatic secreted factor. These findings shed light on the molecular mechanisms that enable single cancer cells to form allochthonous tumors in foreign tissue environments.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Brady, Jennifer J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chuang, Chen-HuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenside, Peyton G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogers, Zoe N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, Christopher W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caswell, Deborah R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Connolly, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sweet-Cordero, E. AlejandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kundaje, AnshulUNSPECIFIEDorcid.org/0000-0003-3084-2287UNSPECIFIED
Winslow, Monte M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-275821
DOI: 10.1016/j.ccell.2016.03.003
Journal or Publication Title: Cancer Cell
Volume: 29
Number: 5
Page Range: S. 697 - 711
Date: 2016
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1878-3686
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BREAST-CANCER METASTASIS; EXTRACELLULAR-MATRIX; PROGRESSION; CELLS; TRANSCRIPTION; PROTEIN; BONE; INVASION; DIFFERENTIATION; DISSEMINATIONMultiple languages
Oncology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27582

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