Universität zu Köln

Babu, Vipin ORCID: 0000-0002-0001-8783 and Schumacher, Bjoern (2016). A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair, 41. S. 8 - 16. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1568-7856

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Abstract

The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking DNA lesions, particularly UV-induced damage. Clinical symptoms of the two TC-NER-deficiency syndromes, Cockayne syndrome (CS) and UV-hypersensitivity syndrome (UVSS) are dissimilar and the underlying molecular mechanism causing this difference in disease pathology is not yet clearly understood. UV-stimulated scaffold protein A (UVSSA) has been identified recently as a new causal gene for UVSS. Here we describe a functional homolog of the human UVSSA gene in the nematode Caenorhabditis elegans, uvs-1 (UVSSA-like-1). Mutations in uvs-1 render the animals hypersensitive to UV-B irradiation and transcription-blocking lesion-inducing illudin-M, similar to mutations in TC-NER deficient mutants. Moreover, we demonstrate that TC-NER factors including UVS-1 are required for the survival of the adult animals after UV-treatment. (c) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Babu, Vipin UNSPECIFIED orcid.org/0000-0002-0001-8783 UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276802
DOI:	10.1016/j.dnarep.2016.03.008
Journal or Publication Title:	DNA Repair
Volume:	41
Page Range:	S. 8 - 16
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1568-7856
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE-EXCISION-REPAIR; SENSITIVE SYNDROME; COCKAYNE-SYNDROME; CAENORHABDITIS-ELEGANS; DNA-DAMAGE; XERODERMA-PIGMENTOSUM; THYMINE DIMERS; COUPLED REPAIR; 8-OXOGUANINE; FIBROBLASTS Multiple languages Genetics & Heredity; Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27680