Gurska, Daniela ORCID: 0000-0001-7756-5331, Vargas Jentzsch, Iris M. and Panfilio, Kristen A. (2020). Unexpected mutual regulation underlies paralogue functional diversification and promotes epithelial tissue maturation inTribolium. Commun. Biol., 3 (1). BERLIN: NATURE RESEARCH. ISSN 2399-3642

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Abstract

InsectHox3/zengenes represent an evolutionary hotspot for changes in function and copy number. Single orthologues are required either for early specification or late morphogenesis of the extraembryonic tissues, which protect the embryo. The tandemly duplicatedzenparalogues of the beetleTribolium castaneumpresent a unique opportunity to investigate both functions in a single species. We dissect the paralogues' expression dynamics (transcript and protein) and transcriptional targets (RNA-seq after RNAi) throughout embryogenesis. We identify an unexpected role of Tc-Zen2 in repression ofTc-zen1, generating a negative feedback loop that promotes developmental progression. Tc-Zen2 regulation is dynamic, including within co-expressed multigene loci. We also show that extraembryonic development is the major event within the transcriptional landscape of late embryogenesis and provide a global molecular characterization of the extraembryonic serosal tissue. Altogether, we propose that paralogue mutual regulation arose through multiple instances ofzensubfunctionalization, leading to their complementary extant roles. Gurska et al. dissect the expression and function ofzengenes (Hox3in mammals) in the beetleTribolium castaneum. They identify dynamic regulatory interactions of the tandemly duplicated paralogues that support extraembryonic development, under a scenario of evolutionary subfunctionalization.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gurska, DanielaUNSPECIFIEDorcid.org/0000-0001-7756-5331UNSPECIFIED
Vargas Jentzsch, Iris M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panfilio, Kristen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-315728
DOI: 10.1038/s42003-020-01250-3
Journal or Publication Title: Commun. Biol.
Volume: 3
Number: 1
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2399-3642
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRIBOLIUM EMBRYOGENESIS; HOX GENES; DROSOPHILA; EVOLUTION; EXPRESSION; MORPHOGENESIS; SEQUENCE; HOX3/ZEN; COMPLEX; PROTEINMultiple languages
Biology; Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31572

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