Universität zu Köln

Goergens, Christian, Walker, Katherine, Boeser, Cornelia, Wijeratne, Neloni, Martins, Claudia, Guddat, Sven and Thevis, Mario (2020). Paper spray mass spectrometry - A potential complementary technique for the detection of polar compounds in sports drug testing. Drug Test. Anal., 12 (11-12). S. 1658 - 1666. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

In this proof-of-concept study, paper spray mass spectrometry was investigated as a high-throughput and fully automated technique for the initial testing of particularly polar compounds that are prohibited in sports. The technique allows the ionization of analytes from complex sample matrices such as blood and urine when spotted onto a paper strip. By minimizing sample preparation and omitting chromatographic separation, paper spray mass spectrometry benefits from considerable cost- and time-savings compared with conventional high performance liquid chromatography/tandem mass spectrometry, especially in cases where conventional reversed-phase liquid chromatography offers limited applicability. All but one of the investigated model compounds fulfilled the World Anti-Doping Agency's (WADA's) requirements regarding the applicable minimum required performance limits for initial testing procedures. In addition, the combination of paper spray mass spectrometry and ion mobility separation results in enhanced selectivity and sensitivity and is a particularly valuable analytical configuration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goergens, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Walker, Katherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Boeser, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wijeratne, Neloni UNSPECIFIED UNSPECIFIED UNSPECIFIED Martins, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Guddat, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319493
DOI:	10.1002/dta.2909
Journal or Publication Title:	Drug Test. Anal.
Volume:	12
Number:	11-12
Page Range:	S. 1658 - 1666
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHROMATOGRAPHY-HIGH-RESOLUTION; HUMAN URINE; SCREENING METHOD; DOPING AGENTS; STIMULANTS; DIURETICS; CONFIRMATION Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31949