Inoda, Satoru ORCID: 0000-0003-4577-8169, Hayashi, Takahiko ORCID: 0000-0001-8704-680X, Takahashi, Hidenori ORCID: 0000-0001-5331-4730, Oyakawa, Itaru, Yokogawa, Hideaki, Kobayashi, Akira, Kato, Naoko ORCID: 0000-0002-6670-2043 and Kawashima, Hidetoshi (2020). Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia. PLoS One, 15 (6). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Purpose To investigate the factors associated with endothelial survival after Descemet's membrane endothelial keratoplasty (DMEK) in eyes of Asian patients with bullous keratopathy (BK). Methods In this retrospective, consecutive interventional case series, 72 eyes of 72 patients who underwent DMEK were evaluated. Best corrected visual acuity (BCVA) and corneal endothelial cell density (ECD) were assessed at 12 months postoperatively. Multiple regression analysis was performed to assess parameters such as age, sex, axial length, preoperative visual acuity, re-bubbling, the ratio of graft to cornea area, iris damage scores, types of filling gases, air or SF(6)volume in the anterior chamber (AC) on postoperative day 1, and ECD loss rates at 12 months postoperatively. Results BCVA improved significantly at 12 months after DMEK (P< .001). The rate of ECD loss at 12 months after DMEK was 54.4 +/- 16.1%. Multiple linear regression analysis showed that a larger ratio of graft to corneal area (P= 0.0061) and higher donor ECD (P= 0.042) were the primary factors for a lower ECD loss rate at 12 months after DMEK. Conclusion A relatively larger graft size compared to the host cornea and more donor ECD might help endothelial survival in patients with BK. Moreover, for such patients, the surgeon should attempt to use a relatively larger graft size when performing DMEK, particularly in Asian eyes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Inoda, SatoruUNSPECIFIEDorcid.org/0000-0003-4577-8169UNSPECIFIED
Hayashi, TakahikoUNSPECIFIEDorcid.org/0000-0001-8704-680XUNSPECIFIED
Takahashi, HidenoriUNSPECIFIEDorcid.org/0000-0001-5331-4730UNSPECIFIED
Oyakawa, ItaruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yokogawa, HideakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobayashi, AkiraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kato, NaokoUNSPECIFIEDorcid.org/0000-0002-6670-2043UNSPECIFIED
Kawashima, HidetoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-330112
DOI: 10.1371/journal.pone.0234202
Journal or Publication Title: PLoS One
Volume: 15
Number: 6
Date: 2020
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GRAFT-SURVIVAL; PENETRATING KERATOPLASTY; CORNEAL ENDOTHELIUM; SURGICAL INDICATION; RISK-FACTORS; EYES; OUTCOMESMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33011

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