Chakroun, Karima, Mathar, David, Wiehler, Antonius, Ganzer, Florian and Peters, Jan ORCID: 0000-0002-0195-5357 (2020). Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

Full text not available from this repository.

Abstract

Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functional magnetic resonance imaging to address this issue. Thirty-one healthy male participants performed a restless four-armed bandit task in a within-subjects design under three drug conditions: 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo. Choices were best explained by an extension of an established Bayesian learning model accounting for perseveration, directed exploration and random exploration. Modeling revealed attenuated directed exploration under L-dopa, while neural signatures of exploration, exploitation and prediction error were unaffected. Instead, L-dopa attenuated neural representations of overall uncertainty in insula and dorsal anterior cingulate cortex. Our results highlight the computational role of these regions in exploration and suggest that dopamine modulates how this circuit tracks accumulating uncertainty during decision-making.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chakroun, KarimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathar, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiehler, AntoniusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganzer, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, JanUNSPECIFIEDorcid.org/0000-0002-0195-5357UNSPECIFIED
URN: urn:nbn:de:hbz:38-330754
DOI: 10.7554/eLife.51260
Journal or Publication Title: eLife
Volume: 9
Date: 2020
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VENTROMEDIAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; WORKING-MEMORY CAPACITY; PREDICTION ERRORS; INDIVIDUAL-DIFFERENCES; STRIATAL DOPAMINE; HUMAN BRAIN; NEURAL MECHANISMS; SEEKING BEHAVIOR; VALUATION SYSTEMMultiple languages
BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33075

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item