Universität zu Köln

Dafsari, Forugh S. and Jessen, Frank (2020). Depression-an underrecognized target for prevention of dementia in Alzheimer's disease. Transl. Psychiatr., 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2158-3188

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Abstract

It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be modifiable by the management of risk factors. While several recent guidelines and multidomain intervention trials on prevention of cognitive decline address lifestyle factors and risk diseases, such as hypertension and diabetes, a special reference to the established risk factor of depression or depressive symptoms is systematically lacking. In this article we review epidemiological studies and biological mechanisms linking depression with AD and cognitive decline. We also emphasize the effects of antidepressive treatment on AD pathology including the molecular effects of antidepressants on neurogenesis, amyloid burden, tau pathology, and inflammation. We advocate moving depression and depressive symptoms into the focus of prevention of cognitive decline and dementia. We constitute that early treatment of depressive symptoms may impact on the disease course of AD and affect the risk of developing dementia and we propose the need for clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dafsari, Forugh S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333357
DOI:	10.1038/s41398-020-0839-1
Journal or Publication Title:	Transl. Psychiatr.
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2158-3188
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; LATE-LIFE DEPRESSION; INDUCED TAU HYPERPHOSPHORYLATION; AMYLOID-BETA; HIPPOCAMPAL NEUROGENESIS; ANTIDEPRESSANT TREATMENT; CEREBROSPINAL-FLUID; CELL-PROLIFERATION; RISK-FACTOR; SYMPTOMS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33335