Universität zu Köln

Lauterbach, Lukas, Goldfuss, Bernd ORCID: 0000-0002-1814-8818 and Dickschat, Jeroen S. (2020). Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase. Angew. Chem.-Int. Edit., 59 (29). S. 11943 - 11948. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1521-3773

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Abstract

Two bacterial diterpene synthases (DTSs) from Chryseobacterium were characterised. The first enzyme yielded the new compound chryseodiene that closely resembles the known fusicoccane diterpenes from fungi, but its experimentally and computationally studied cyclisation mechanism is fundamentally different to the mechanism of fusicoccadiene synthase. The second enzyme produced wanjudiene, a diterpene hydrocarbon with a new skeleton, besides traces of the enantiomer of bonnadiene that was recently discovered from Allokutzneria albata.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lauterbach, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldfuss, Bernd UNSPECIFIED orcid.org/0000-0002-1814-8818 UNSPECIFIED Dickschat, Jeroen S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333572
DOI:	10.1002/anie.202004691
Journal or Publication Title:	Angew. Chem.-Int. Edit.
Volume:	59
Number:	29
Page Range:	S. 11943 - 11948
Date:	2020
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1521-3773
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOSYNTHETIC GENE-CLUSTER; RAPID CHEMICAL-CHARACTERIZATION; HETEROLOGOUS EXPRESSION; PROTON-TRANSFER; IDENTIFICATION; PURIFICATION; CYCLIZATION; CYCLASE; CLONING Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33357