Duda, Dan G., Dima, Simona O., Cucu, Dana, Sorop, Andrei, Klein, Sebastian ORCID: 0000-0002-2188-9377, Ancukiewicz, Marek, Kitahara, Shuji ORCID: 0000-0002-2904-0319, Iacob, Speranta, Bacalbasa, Nicolae, Tomescu, Dana ORCID: 0000-0001-9673-5754, Herlea, Vlad, Tanase, Cristiana, Croitoru, Adina and Popescu, Irinel (2020). Potential Circulating Biomarkers of Recurrence after Hepatic Resection or Liver Transplantation in Hepatocellular Carcinoma Patients. Cancers, 12 (5). BASEL: MDPI. ISSN 2072-6694

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Abstract

Background: Improving surgical outcomes in hepatocellular carcinoma (HCC) patients would greatly benefit from biomarkers. Angiogenesis and inflammation are hallmarks of HCC progression and therapeutic targets. Methods: We retrospectively evaluated preoperative clinical variables and circulating (plasma) biomarkers of angiogenesis and inflammation in a cohort of HCC patients who underwent liver resection (LR) or transplantation (LT). Biomarker correlation with outcomes-freedom of liver recurrence (FLR), disease-free survival (DFS) and overall survival (OS)-was tested using univariate and multivariate Cox regression analyses. Results: Survival outcomes associated with sVEGFR1, VEGF and VEGF-C in LT patients and with IL-10 in LR patients. Moreover, in LT patients within Milan criteria, higher plasma VEGF and sVEGFR1 were associated with worse outcomes, while in those outside Milan criteria lower plasma VEGF-C associated with better outcomes. Multivariate analysis indicated that adding plasma VEGF or VEGF-C to a predictive model including Milan criteria and AFP improved prediction of DFS and OS (all p < 0.05). Conclusion: Survival outcomes after LR or LT differentially associated with angiogenic and inflammatory biomarkers. High plasma VEGF correlated with poorer prognosis within Milan criteria while low plasma VEGF-C associated with better prognosis outside Milan criteria. These candidate biomarkers should be further validated to improve patient stratification.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Duda, Dan G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dima, Simona O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cucu, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorop, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, SebastianUNSPECIFIEDorcid.org/0000-0002-2188-9377UNSPECIFIED
Ancukiewicz, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kitahara, ShujiUNSPECIFIEDorcid.org/0000-0002-2904-0319UNSPECIFIED
Iacob, SperantaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bacalbasa, NicolaeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomescu, DanaUNSPECIFIEDorcid.org/0000-0001-9673-5754UNSPECIFIED
Herlea, VladUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanase, CristianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Croitoru, AdinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popescu, IrinelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-334914
DOI: 10.3390/cancers12051275
Journal or Publication Title: Cancers
Volume: 12
Number: 5
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6694
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENDOTHELIAL GROWTH-FACTOR; MILAN CRITERIA; SOLUBLE VEGFR-1; SORAFENIB; CANCER; MODEL; ANGIOGENESIS; ASSOCIATION; EXPRESSION; PROGNOSISMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33491

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