Universität zu Köln

Amit, M., Yen, T. C., Liao, C. T., Chaturvedi, P., Agarwal, J. P., Kowalski, L. P., Kohler, Hugo F., Ebrahimi, A., Clark, J. R., Cernea, C. R., Brandao, S. J., Kreppel, M., Zoeller, J., Fliss, M. D., Bachar, G., Shpitzer, T., Bolzoni, V. A., Patel, P. R., Jonnalagadda, S., Robbins, K. T., Iyer, N. G., Skanthakumar, T., Shah, J. P., Patel, S. G. and Gil, Z. (2015). Prognostic Performance of Current Stage III Oral Cancer Patients After Curative Intent Resection: Evidence to Support a Revision of the American Joint Committee on Cancer Staging System. Ann. Surg. Oncol., 22. S. S985 - 7. NEW YORK: SPRINGER. ISSN 1534-4681

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Abstract

Background. The American Joint Committee on Cancer (AJCC) stage III classification of oral cavity squamous cell carcinoma (OCSCC) represents a heterogeneous group of patients with early local disease with regional metastases (T1N1 and T2N1) and advanced local disease with or without regional metastasis (T3N0 and T3N1). Objective. The aim of this study was to evaluate prognostic heterogeneity in the stage III category. Methods and Patients. An international retrospective multicenter study of 1815 patients who were treated for OCSCC from 2003 to 2011. Results. Kaplan-Meier survival analysis and multivariate models of stage III patients revealed better overall survival (OS; HR 2.12, 95 % CI 1.03-4.15; p = 0.01) and disease-specific survival (DSS; HR 1.7, 95 % CI 1.16-4.12; p = 0.04) rates for patients with T1-2N1/T3N0 disease than for patients with T3N1 disease. The outcomes of patients with T3N1 and stage IVa disease were similar (p = 0.89 and p = 0.78 for OS and DSS, respectively). Modifying stage classification by transferring the T3N1 category to the stage VIa group resulted in a better prognostic performance [Harrell's concordance index, C index 0.76; Akaike's Information Criterion (AIC) 4131.6] compared with the AJCC 7th edition staging system (C index 0.65; AIC 4144.9) for OS. When DSS was assessed, the suggested staging system remained the best performing model (C index 0.71; AIC 1061.3) compared with the current AJCC 7th edition staging (C index 0.64; AIC 1066.2). Conclusions. The prognosis of T3N1 and stage IVa disease are similar in OCSCC, suggesting that these categories could be combined in future revisions of the nodal staging system to enhance prognostic accuracy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Amit, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, T. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, C. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaturvedi, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, L. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohler, Hugo F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernea, C. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandao, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliss, M. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachar, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shpitzer, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolzoni, V. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, P. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonnalagadda, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Robbins, K. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Iyer, N. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skanthakumar, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, S. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-384886
DOI:	10.1245/s10434-015-4842-3
Journal or Publication Title:	Ann. Surg. Oncol.
Volume:	22
Page Range:	S. S985 - 7
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1534-4681
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; POSTOPERATIVE RADIOTHERAPY; NECK DISSECTION; CHEMOTHERAPY; METAANALYSIS; IRRADIATION; TOMOGRAPHY; METASTASIS; MANAGEMENT Multiple languages Oncology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38488