Balabanova, Yanina, Nikolayevskyy, Vladyslav ORCID: 0000-0002-9502-0332, Ignatyeva, Olga ORCID: 0000-0003-2020-4206, Kontsevaya, Irina ORCID: 0000-0003-3421-7550, Mironova, Svetlana, Kovalyov, Alexander, Kritsky, Andrey, Rodionova, Yulia, Fedorin, Ivan, Casali, Nicola, Hooper, Richard ORCID: 0000-0002-1063-0917, Horstmann, Rolf D., Nejentsev, Sergey, Hoffner, Sven, Nuernberg, Peter and Drobniewski, Francis (2015). Beijing clades of Mycobacterium tuberculosis are associated with differential survival in HIV-negative Russian patients. Infect. Genet. Evol., 36. S. 517 - 524. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1567-7257

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Abstract

We conducted a prospective study to establish factors associated with survival in tuberculosis patients in Russia including social, clinical and pathogen-related genetic parameters. Specifically we wished to determine whether different strains/clades of the Beijing lineage exerted a differential effect of survival. HIV-negative culture-confirmed cases were recruited during 2008-2010 across Samara Oblast and censored in December 2011. Molecular characterization was performed by a combination of spoligotyping, multilocus VNTR typing and whole genome sequencing (WGS). We analyzed 2602 strains and detected a high prevalence of Beijing family (n=1933; 74%) represented largely by two highly homogenous dominant clades A (n=794) and B (n=402) and non-A/non-B (n=737). Multivariable analysis of 1366 patients with full clinical and genotyping data showed that multi-and extensive drug resistance (HR = 1.86; 95%CI: 1.52, 2.28 and HR = 2.19; 95%CI: 1.55, 3.11) had the largest impact on survival. In addition older age, extensive lung damage, shortness of breath, treatment in the past and alcohol abuse reduced survival time. After adjustment for clinical and demographic predictors there was evidence that clades A and B combined were associated with poorer survival than other Beijing strains (HR = 0.48; 95%CI 0.34, 0.67). All other pathogen-related factors (polymorphisms in genes plcA, plcB, plcC, lipR, dosT and pks15/1) had no effect on survival. In conclusion, drug resistance exerted the greatest effect on survival of TB patients. Nevertheless we provide evidence for the independent biological effect on survival of different Beijing family strains even within the same defined geographical population. Better understanding of the role of different strain factors in active disease and their influence on outcome is essential. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Balabanova, YaninaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nikolayevskyy, VladyslavUNSPECIFIEDorcid.org/0000-0002-9502-0332UNSPECIFIED
Ignatyeva, OlgaUNSPECIFIEDorcid.org/0000-0003-2020-4206UNSPECIFIED
Kontsevaya, IrinaUNSPECIFIEDorcid.org/0000-0003-3421-7550UNSPECIFIED
Mironova, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovalyov, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kritsky, AndreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodionova, YuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fedorin, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casali, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooper, RichardUNSPECIFIEDorcid.org/0000-0002-1063-0917UNSPECIFIED
Horstmann, Rolf D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nejentsev, SergeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffner, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drobniewski, FrancisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-386025
DOI: 10.1016/j.meegid.2015.08.028
Journal or Publication Title: Infect. Genet. Evol.
Volume: 36
Page Range: S. 517 - 524
Date: 2015
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1567-7257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DRUG-RESISTANT TUBERCULOSIS; GENETIC POLYMORPHISMS; STRAINS; FAMILY; POPULATION; DIVERSITY; EMERGENCE; GENOTYPE; SPREADMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38602

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