Universität zu Köln

Montesinos-Rongen, Manuel, Purschke, Frauke, Kueppers, Ralf and Deckert, Martina (2014). Immunoglobulin Repertoire of Primary Lymphomas of the Central Nervous System. J. Neuropathol. Exp. Neurol., 73 (12). S. 1116 - 1126. CARY: OXFORD UNIV PRESS INC. ISSN 1554-6578

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Abstract

Primary lymphoma of the central nervous system (PCNSL) is a diffuse large B-cell lymphoma confined to the CNS. It has been hypothesized that antigen(s) in the CNS may trigger tumor cell proliferation. Because efforts to identify potential antigens have been unsuccessful to date, we studied the B-cell receptor in detail in a comprehensive series of 50 PCNSLs to obtain indirect information on potential antigens. Potentially functional V-D-J rearrangements were identified in all PCNSLs analyzed. Immunoglobulin heavy-chain variable gene segment (IGHV), IGHV4, was the predominant family used by 66% (33 of 50) of PCNSLs with a preferential rearrangement of the IGHV4-34 gene segment (18 [55%] of 33). The IGHV genes showed mutation frequencies from 0% to 29%, with a high average mutation frequency of 10%. In addition to 48% (24 of 50) of PCNSLs being highly mutated, 22% (11 of 50) defined a low-level mutated group. Antigen selection of the tumor cells or their precursors was indicated by replacement/silent mutation ratios and ongoing somatic hypermutation. Complementarity determining region 3 length and composition as well as the lack of stereotyped B-cell receptors suggest involvement of several antigens instead of a unique antigen recognized by the tumor cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Montesinos-Rongen, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Purschke, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Kueppers, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422160
DOI:	10.1097/NEN.0000000000000133
Journal or Publication Title:	J. Neuropathol. Exp. Neurol.
Volume:	73
Number:	12
Page Range:	S. 1116 - 1126
Date:	2014
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1554-6578
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELL LYMPHOMAS; CHRONIC LYMPHOCYTIC-LEUKEMIA; PRIMARY CNS LYMPHOMA; SOMATIC HYPERMUTATION; MOLECULAR CHARACTERIZATION; V-H; FOLLICULAR LYMPHOMA; VARIABLE REGION; GENE; BCL6 Multiple languages Clinical Neurology; Neurosciences; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42216