Universität zu Köln

Nosseir, N. S., Michels, G., Pfister, R., Adam, R., Wiesen, M. H. J. and Mueller, C. (2014). Therapeutic Drug Monitoring of antiinfectives in intensive care medicine. Dtsch. Med. Wochenschr., 139 (38). S. 1889 - 1895. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

Therapeutic Drug Monitoring (TDM) is based on drug-level control in biological matrices and serves as a diagnostic approach for individualization of pharmacotherapy and drug safety. Drug levels of antibiotics are distinctly influenced by comorbidity, physiological changes and various concomitant drugs in patients on intensive care units. Several factors should be taken into account for calculation of relevant pharmacokinetic parameters (elimination half-life, bioavailability, and clearance) to deduce a recommendation for dosage. TDM is a diagnostic standard for the individualization of polypharmcotherapy based on validated analytical methods (in particular LC-MS/MS and HPLC-methods) in order to optimize dosing and drug safety.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nosseir, N. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiesen, M. H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-429990
DOI:	10.1055/s-0034-1387215
Journal or Publication Title:	Dtsch. Med. Wochenschr.
Volume:	139
Number:	38
Page Range:	S. 1889 - 1895
Date:	2014
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4413
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTINUOUS VENOVENOUS HEMOFILTRATION; RENAL REPLACEMENT THERAPY; CRITICALLY-ILL PATIENTS; CONTINUOUS-INFUSION; PSEUDOMONAS-AERUGINOSA; UNIT PATIENTS; VANCOMYCIN; PHARMACOKINETICS; NEPHROTOXICITY; NEUROTOXICITY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42999