Universität zu Köln

Srinivasan, Murali ORCID: 0000-0003-3365-576X, Schimmel, Martin ORCID: 0000-0001-9700-5534, Riesen, Martine, Ilgner, Alexander, Wicht, Michael J., Warncke, Michael, Ellwood, Roger P., Nitschke, Ina, Mueller, Frauke and Noack, Michael J. (2014). High-fluoride toothpaste: a multicenter randomized controlled trial in adults. Community Dentist. Oral Epidemiol., 42 (4). S. 333 - 341. HOBOKEN: WILEY. ISSN 1600-0528

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Abstract

Objective: The aim of this single - blind, multicenter, parallel, randomized controlled trial was to evaluate the effectiveness of the application of a high-fluoride toothpaste on root caries in adults. Methods: Adult patients (n = 130, male = 74, female = 56; mean age +/- SD: 56.9 +/- 12.9) from three participating centers, diagnosed with root caries, were randomly allocated into two groups: Test (n = 64, male = 37, female = 27; lesions = 144; mean age: 59.0 +/- 12.1; intervention: high-fluoride toothpaste with 5000 ppm F), and Control (n = 66, male = 37, female = 29; lesions = 160; mean age: 54.8 +/- 13.5; intervention: regular-fluoride toothpaste with 1350 ppm F) groups. Clinical examinations and surface hardness scoring of the carious lesions were performed for each subject at specified time intervals (T-0 - at baseline before intervention, T-1 - at 3 months and T-2 - at 6 months after intervention). Mean surface hardness scores (HS) were calculated for each patient. Statistical analyses comprised of two-way analysis of variance and post hoc comparisons using the Bonferroni-Dunn correction. Results: At T-0, there was no statistical difference between the two groups with regard to gender (P = 0.0682, unpaired t-test), or age (P = 0.9786, chi-squared test), and for the overall HS (Test group: HS = 3.4 +/- 0.61; Control group: HS = 3.4 +/- 0.66; P = 0.8757, unpaired t-test). The ANOVA revealed significantly better HS for the test group than for the control groups (T-1: Test group: HS = 2.9 +/- 0.67; Control group: HS = 3.1 +/- 0.75; T-2:Test group: HS = 2.4 +/- 0.81; Control group: HS = 2.8 +/- 0.79; P < 0.0001). However, the interaction term time-point*group was not significant. Conclusions: The application of a high-fluoride containing dentifrice (5000 ppm F) in adults, twice daily, significantly improves the surface hardness of otherwise untreated root caries lesions when compared with the use of regular fluoride containing (1350 ppm F) toothpastes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Srinivasan, Murali UNSPECIFIED orcid.org/0000-0003-3365-576X UNSPECIFIED Schimmel, Martin UNSPECIFIED orcid.org/0000-0001-9700-5534 UNSPECIFIED Riesen, Martine UNSPECIFIED UNSPECIFIED UNSPECIFIED Ilgner, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wicht, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Warncke, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellwood, Roger P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nitschke, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Noack, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432495
DOI:	10.1111/cdoe.12090
Journal or Publication Title:	Community Dentist. Oral Epidemiol.
Volume:	42
Number:	4
Page Range:	S. 333 - 341
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0528
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY ROOT-CARIES; TREATMENT NEEDS; CLINICAL-TRIAL; LESIONS; DENTIFRICES; REVERSAL; COMBINATION; RETENTION; VARNISHES; SEVERITY Multiple languages Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43249