Universität zu Köln

Mecocci, P., Tinarelli, C., Schulz, R. J. and Polidori, M. C. (2014). Nutraceuticals in cognitive impairment and Alzheimer's disease. Front. Pharmacol., 5. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-9812

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Abstract

Several chemical substances belonging to classes of natural dietary origin display protective properties against some age-related diseases including neurodegenerative ones, particularly Alzheimer's disease (AD). These compounds, known as nutraceuticals, differ structurally, act therefore at different biochemical and metabolic levels and have shown different types of neuroprotective properties. The aim of this review is to summarize data from observational studies, clinical trials, and randomized clinical trials (RCTs) in humans on the effects of selected nutraceuticals against age-related cognitive impairment and dementia. We report results from studies on flavonoids, some vitamins and other natural substances that have been studied in AD and that might be beneficial for the maintenance of a good cognitive performance. Due to the substantial lack of high-level evidence studies there is no possibility for recommendation of nutraceuticals in dementia-related therapeutic guidelines. Nevertheless, the strong potential for their neuroprotective action warrants further studies in the field.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mecocci, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tinarelli, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, R. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-435655
DOI:	10.3389/fphar.2014.00147
Journal or Publication Title:	Front. Pharmacol.
Volume:	5
Date:	2014
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-9812
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPPLEMENTATION IMPROVES MEMORY; SOY ISOFLAVONE SUPPLEMENTATION; SPATIAL WORKING-MEMORY; GINKGO-BILOBA EXTRACT; N-3 FATTY-ACIDS; VITAMIN-E FORMS; OXIDATIVE STRESS; MEDITERRANEAN DIET; DOUBLE-BLIND; FOLIC-ACID Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43565