Krug, A., Cabanis, M., Pyka, M., Pauly, K., Walter, H., Landsberg, M., Shah, N. Jon ORCID: 0000-0002-8151-6169, Winterer, G., Woelwer, W., Musso, F., Mueller, B. W., Wiedemann, G., Herrlich, J., Schnell, K., Vogeley, K., Schilbach, L., Langohr, K., Rapp, A., Klingberg, S. and Kircher, T. (2014). Investigation of decision-making under uncertainty in healthy subjects: A multi-centric fMRI study. Behav. Brain Res., 261. S. 89 - 97. AMSTERDAM: ELSEVIER. ISSN 1872-7549

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Abstract

Decision-making is an everyday routine that entails several subprocesses. Decisions under uncertainty occur when either prior information is incomplete or the outcomes of the decision are unclear. The aim of the present study was to disentangle the neural correlates of information gathering as well as reaching a decision and to explore effects of uncertainty acceptance or avoidance in a large sample of healthy subjects. Sixty-four healthy volunteers performed a decision-making under uncertainty task in a multi-center approach while BOLD signal was measured with fMRI. Subjects either had to indicate via button press from which of two bottles red or blue balls were drawn (decision-making under uncertainty condition), or they had to indicate whether 8 red balls had been presented (baseline condition). During the information gathering phase (contrasted against the counting phase) a widespread network was found encompassing (pre-)frontal, inferior temporal and inferior parietal cortices. Reaching a decision was correlated with activations in the medial frontal cortex as well as the posterior cingulate and the precuneus. Effects of uncertainty acceptance were found within a network comprising of the superior frontal cortex as well as the insula and precuneus while uncertainty avoidance was correlated with activations in the right middle frontal cortex. The results depict two distinct networks for information gathering and the indication of having made a decision. While information-gathering networks are modulated by uncertainty avoidance and acceptance, underlying networks of the decision itself are independent of these factors. (C) 2013 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Krug, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabanis, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pyka, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauly, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landsberg, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, N. JonUNSPECIFIEDorcid.org/0000-0002-8151-6169UNSPECIFIED
Winterer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woelwer, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musso, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, B. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiedemann, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrlich, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnell, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogeley, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schilbach, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langohr, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rapp, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingberg, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kircher, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-443372
DOI: 10.1016/j.bbr.2013.12.013
Journal or Publication Title: Behav. Brain Res.
Volume: 261
Page Range: S. 89 - 97
Date: 2014
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1872-7549
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WORKING-MEMORY TASK; BRAIN ACTIVATION; CORTEX; CHOICE; NEUROBIOLOGY; CONFIDENCE; MECHANISMS; DISTINCTMultiple languages
Behavioral Sciences; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44337

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