Kalbe, Elke and Petrelli, Annette (2014). Mild Cognitive Impairment and Dementia in Patients with Parkinson's Disease. Z. Neuropsychol., 25 (1). S. 17 - 31. BERN 9: VERLAG HANS HUBER. ISSN 1664-2902

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Abstract

Cognitive deficits are frequent symptoms in patients with Parkinson's disease (PD) and typically include executive dysfunctions, memory dysfunctions (especially regarding strategic encoding and retrieval) as well as deficits in visuo-spatial functions and attention. The estimated point prevalence of mild cognitive impairment in PD patients (PD-MCI) for which research criteria were published in 2012 is 27 %, and further 30 % of the patients are estimated to suffer from Parkinson's Disease Dementia (PDD); longitudinally, most patients develop cognitive dysfunctions during the course of the disease. Given that these symptoms are highly frequent and of utmost relevance, neuropsychological diagnostics should be performed in all PD patients. The acetylcholinesterase inhibitor rivastigmine is approved for the treatment of PDD; other approved treatment options for cognitive dysfunctions in PD patients do not exist yet. Evidence of efficacy of non-pharmacological interventions is insufficient. However, first studies with cognitive training and exercise are promising.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrelli, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-444616
DOI: 10.1024/1016-264X/a000115
Journal or Publication Title: Z. Neuropsychol.
Volume: 25
Number: 1
Page Range: S. 17 - 31
Date: 2014
Publisher: VERLAG HANS HUBER
Place of Publication: BERN 9
ISSN: 1664-2902
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; EXECUTIVE FUNCTIONS; WORKING-MEMORY; LEWY BODIES; DIAGNOSTIC-CRITERIA; CHOLINERGIC DRUGS; ASSESSMENT PANDA; RATING-SCALES; DOUBLE-BLINDMultiple languages
Clinical Neurology; PsychologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44461

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