Universität zu Köln

Vyas, Maulik ORCID: 0000-0003-2996-4682, Koehl, Ulrike ORCID: 0000-0002-8159-9160, Hallek, Michael and von Strandmann, Elke Pogge (2014). Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer. Trends Mol. Med, 20 (2). S. 72 - 83. OXFORD: ELSEVIER SCI LTD. ISSN 1471-499X

Full text not available from this repository.

Abstract

The insight that the immune system is able to eradicate tumor cells inspired the development of targeted immunotherapies. These novel approaches aim to trigger immune molecules and receptors, including CD3 on T cells and NKG2D and NKp30 on natural killer (NK) cells, to harness the immune system against cancer. In cancer patients, overcoming immune suppression induced by malignant cells or by the tumor microenvironment remains the major challenge to the clinical efficacy of immunotherapies. Recombinant constructs have been developed in various formats either utilizing natural ligands (immunoligands) or antibody-derived components (immunoconstructs) to circumvent mechanisms that counteract an effective antitumor immune response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vyas, Maulik UNSPECIFIED orcid.org/0000-0003-2996-4682 UNSPECIFIED Koehl, Ulrike UNSPECIFIED orcid.org/0000-0002-8159-9160 UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED von Strandmann, Elke Pogge UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447055
DOI:	10.1016/j.molmed.2013.10.006
Journal or Publication Title:	Trends Mol. Med
Volume:	20
Number:	2
Page Range:	S. 72 - 83
Date:	2014
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-499X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYELOID-LEUKEMIA; NK-CELL CYTOTOXICITY; B-ASSOCIATED TRANSCRIPT-3; I-RELATED CHAIN; T-CELLS; TUMOR-CELLS; THERAPEUTIC ANTIBODIES; BISPECIFIC ANTIBODIES; MONOCLONAL-ANTIBODIES; EFFECTIVE ELIMINATION Multiple languages Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44705