Universität zu Köln

Heger, Peter ORCID: 0000-0003-2583-2981, George, Rebecca and Wiehe, Thomas (2013). SUCCESSIVE GAIN OF INSULATOR PROTEINS IN ARTHROPOD EVOLUTION. Evolution, 67 (10). S. 2945 - 2957. HOBOKEN: WILEY. ISSN 1558-5646

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Abstract

Alteration of regulatory DNA elements or their binding proteins may have drastic consequences for morphological evolution. Chromatin insulators are one example of such proteins and play a fundamental role in organizing gene expression. While a single insulator protein, CTCF (CCCTC-binding factor), is known in vertebrates, Drosophila melanogaster utilizes six additional factors. We studied the evolution of these proteins and show here thatin contrast to the bilaterian-wide distribution of CTCFall other D. melanogaster insulators are restricted to arthropods. The full set is present exclusively in the genus Drosophila whereas only two insulators, Su(Hw) and CTCF, existed at the base of the arthropod clade and all additional factors have been acquired successively at later stages. Secondary loss of factors in some lineages further led to the presence of different insulator subsets in arthropods. Thus, the evolution of insulator proteins within arthropods is an ongoing and dynamic process that reshapes and supplements the ancient CTCF-based system common to bilaterians. Expansion of insulator systems may therefore be a general strategy to increase an organism's gene regulatory repertoire and its potential for morphological plasticity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heger, Peter UNSPECIFIED orcid.org/0000-0003-2583-2981 UNSPECIFIED George, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiehe, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-474895
DOI:	10.1111/evo.12155
Journal or Publication Title:	Evolution
Volume:	67
Number:	10
Page Range:	S. 2945 - 2957
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1558-5646
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BOUNDARY-ELEMENT; DROSOPHILA-MELANOGASTER; CHROMATIN INSULATORS; GENE-REGULATION; GAGA FACTOR; HOX GENES; GENOME ORGANIZATION; ENHANCER BLOCKING; BODY PLAN; CTCF Multiple languages Ecology; Evolutionary Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47489