Universität zu Köln

Rieger, C. T., Cornely, O. A., Hoppe-Tichy, T., Kiehl, M., Knoth, H., Thalheimer, M., Schuler, U., Ullmann, A. J., Ehlken, B. and Ostermann, H. (2012). a Treatment cost of invasive fungal disease (Ifd) in patients with acute myelogenous leukaemia (Aml) or myelodysplastic syndrome (Mds) in German hospitals. Mycoses, 55 (6). S. 514 - 521. HOBOKEN: WILEY-BLACKWELL. ISSN 0933-7407

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Abstract

Invasive fungal disease (IFD) causes increasing morbidity and mortality in haematological cancer patients. Reliable cost data for treating IFD in German hospitals is not available. Objective of the study was to determine the institutional cost of treating the IFD. Data were obtained by retrospective chart review in German hospitals. Patients had either newly diagnosed or relapsed acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS). Direct medical cost was calculated from hospital providers perspective. A total of 108 patients were enrolled at 5 tertiary care hospitals, 36 IFD patients and 72 controls. The vast majority of IFD patients (74%) were diagnosed with invasive aspergillosis. On average, the hospital stay for IFD patients was 12 days longer than in control patients. All patients in the IFD group and 89% of patients in the control group received antifungal drugs. Mean direct costs per patient were 51 pound 517 in the IFD group and 30 pound 454 in the control group. Incremental costs of 21 pound 063 were dominated by cost for antifungal drugs (36%), hospital stay (32%) and blood products (23%). From the perspective of hospitals in Germany the economic burden of IFD in patients with AML or MDS is substantial. Therefore, prevention of IFD is necessary with respect to both clinical and economic reasons.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rieger, C. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe-Tichy, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiehl, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knoth, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thalheimer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuler, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullmann, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehlken, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostermann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-480271
DOI:	10.1111/j.1439-0507.2012.02193.x
Journal or Publication Title:	Mycoses
Volume:	55
Number:	6
Page Range:	S. 514 - 521
Date:	2012
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	0933-7407
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONVENTIONAL AMPHOTERICIN-B; ECONOMIC-EVALUATION; ITRACONAZOLE PROPHYLAXIS; NEUTROPENIC PATIENTS; ASPERGILLOSIS; POSACONAZOLE; FLUCONAZOLE; INFECTIONS; VORICONAZOLE; THERAPY Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48027