Mondal, Subhanjan, Burgute, Bhagyashri, Rieger, Daniela, Mueller, Rolf, Rivero, Francisco ORCID: 0000-0001-5435-6991, Faix, Jan, Schleicher, Michael and Noegel, Angelika A. (2010). Regulation of the Actin Cytoskeleton by an Interaction of IQGAP Related Protein GAPA with Filamin and Cortexillin I. PLoS One, 5 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during cytokinesis. Here we describe a novel interaction with Filamin which is required for cytokinesis and regulation of the F-actin content. The interaction occurs through the actin binding domain of Filamin and the GRD domain of GAPA. A similar interaction takes place with Cortexillin I. We further report that Filamin associates with Rac1a implying that filamin might act as a scaffold for small GTPases. Filamin and activated Rac associate with GAPA to regulate actin remodelling. Overexpression of filamin and GAPA in the various strains suggests that GAPA regulates the actin cytoskeleton through interaction with Filamin and that it controls cytokinesis through association with Filamin and Cortexillin.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mondal, SubhanjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgute, BhagyashriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieger, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rivero, FranciscoUNSPECIFIEDorcid.org/0000-0001-5435-6991UNSPECIFIED
Faix, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schleicher, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noegel, Angelika A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-492585
DOI: 10.1371/journal.pone.0015440
Journal or Publication Title: PLoS One
Volume: 5
Number: 11
Date: 2010
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GELATION FACTOR ABP120; DICTYOSTELIUM-DISCOIDEUM; BINDING PROTEINS; CLEAVAGE FURROW; CELL MOTILITY; MONOCLONAL-ANTIBODIES; BUNDLING PROTEIN; HOMOLOGY DOMAIN; TARGETS FILAMIN; CROSS-LINKINGMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49258

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