Mayr, Simon J., Mendel, Ralf-R and Schwarz, Guenter ORCID: 0000-0002-2118-9338 (2021). Molybdenum cofactor biology, evolution and deficiency. Biochim. Biophys. Acta-Mol. Cell Res., 1868 (1). AMSTERDAM: ELSEVIER. ISSN 1879-2596

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Abstract

The molybdenum cofactor (Moco) represents an ancient metal-sulfur cofactor, which participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global scale. Given the diversity of biological processes dependent on Moco and their evolutionary age, Moco is traced back to the last universal common ancestor (LUCA), while Moco biosynthetic genes underwent significant changes through evolution and acquired additional functions. In this review, focused on eukaryotic Moco biology, we elucidate the benefits of gene fusions on Moco biosynthesis and beyond. While originally the gene fusions were driven by biosynthetic advantages such as coordinated expression of functionally related proteins and product/substrate channeling, they also served as origin for the development of novel functions. Today, Moco biosynthetic genes are involved in a multitude of cellular processes and loss of the according gene products result in severe disorders, both related to Moco biosynthesis and secondary enzyme functions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mayr, Simon J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendel, Ralf-RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, GuenterUNSPECIFIEDorcid.org/0000-0002-2118-9338UNSPECIFIED
URN: urn:nbn:de:hbz:38-574764
DOI: 10.1016/j.bbamcr.2020.118883
Journal or Publication Title: Biochim. Biophys. Acta-Mol. Cell Res.
Volume: 1868
Number: 1
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1879-2596
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOLYBDOPTERIN SYNTHASE GENE; THALIANA PROVIDES INSIGHT; BICISTRONIC MOCS1 GENE; C-TERMINAL DOMAIN; NIFS-LIKE DOMAIN; CRYSTAL-STRUCTURE; ALDEHYDE OXIDASE; IRON-SULFUR; PROTEIN CONJUGATION; GENOMIC STRUCTUREMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57476

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