Momotow, Jesko, Borchmann, Sven ORCID: 0000-0001-6662-6864, Eichenauer, Dennis A., Engert, Andreas and Sasse, Stephanie (2021). Hodgkin Lymphoma-Review on Pathogenesis, Diagnosis, Current and Future Treatment Approaches for Adult Patients. J. Clin. Med., 10 (5). BASEL: MDPI. ISSN 2077-0383

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Abstract

Hodgkin lymphoma (HL) is a rare malignancy accounting for roughly 15% of all lymphomas and mostly affecting young patients. A second peak is seen in patients above 60 years of age. The history of HL treatment represents a remarkable success story in which HL has turned from an incurable disease to a neoplasm with an excellent prognosis. First-line treatment with stage-adapted treatment consisting of chemotherapy and/or radiotherapy results in cure rates of approximately 80%. Second-line treatment mostly consists of intensive salvage chemotherapy followed by high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). Novel approaches such as antibody drug conjugates and immunomodulatory drugs have shown impressive results in clinical trials in refractory and relapsed HL and are now increasingly implemented in earlier treatment lines. This review gives a comprehensive overview on HL addressing epidemiology, pathophysiology and current treatment options as well as recent developments and perspectives.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Momotow, JeskoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borchmann, SvenUNSPECIFIEDorcid.org/0000-0001-6662-6864UNSPECIFIED
Eichenauer, Dennis A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sasse, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-575262
DOI: 10.3390/jcm10051125
Journal or Publication Title: J. Clin. Med.
Volume: 10
Number: 5
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELL TRANSPLANTATION; REED-STERNBERG CELLS; TERM-FOLLOW-UP; INVOLVED-FIELD RADIOTHERAPY; HIGH-DOSE CHEMOTHERAPY; BONE-MARROW BIOPSY; BRENTUXIMAB VEDOTIN; PHASE-II; EMISSION-TOMOGRAPHY; ELDERLY-PATIENTSMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57526

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