Herzig-Nichtweiss, Julia, Salih, Farid, Berning, Sascha, Malter, Michael, Pelz, Johann, Lochner, Piergiorgio ORCID: 0000-0002-2101-6066, Wittstock, Matthias, Gunther, Albrecht, Alonso, Angelika, Fuhrer, Hannah, Schonenberger, Silvia, Petersen, Martina, Kohle, Felix ORCID: 0000-0002-4429-0367, Muller, Annekatrin, Gawlitza, Alexander, Gubarev, Waldemar, Holtkamp, Martin and Vorderwulbecke, Bernd (2021). Study protocol: register on the prognosis of acute symptomatic seizures (PROSA register)-A prospective multicenter observational study. Z. Epileptol., 34 (4). S. 349 - 355. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1610-0646

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Abstract

Background Acute symptomatic epileptic seizures occur in close temporal relation to an acute disturbance of brain function. They are associated with a low risk of subsequent unprovoked seizures; thus, current guidelines recommend not to administer a long-term antiseizure medication; however, in clinical practice long-term secondary seizure prophylaxis is frequently initiated. The seizure prognosis after guideline-conform untreated or only briefly treated acute symptomatic seizures, is so far unknown. Hypothesis Following an acute symptomatic first epileptic seizure of structural etiology, the 1-year risk of subsequent unprovoked seizures is not higher than 25%, even if antiseizure medication was not applied or for a short period only. Methods The PROSE register is a single-arm, open, prospective, multicenter observational study. A total of 115 subjects aged 18 years or older with an acute symptomatic first epileptic seizure of structural etiology will be included if the seizure was not a status epilepticus. Intrahospital follow-up will be based on the hospital records. Telephone follow-up interviews will be conducted 3, 6, and 12 months after the acute symptomatic seizure. Discussion The PROSE register will shed light on current treatment practice of acute symptomatic seizures and the actual seizure outcome within 1 year. The results are assumed to support the current evidence that giving antiseizure medication for a longer period of time exceeding the acute phase of the underlying condition is unnecessary.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Herzig-Nichtweiss, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salih, FaridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berning, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelz, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lochner, PiergiorgioUNSPECIFIEDorcid.org/0000-0002-2101-6066UNSPECIFIED
Wittstock, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gunther, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alonso, AngelikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuhrer, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonenberger, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petersen, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohle, FelixUNSPECIFIEDorcid.org/0000-0002-4429-0367UNSPECIFIED
Muller, AnnekatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gawlitza, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gubarev, WaldemarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtkamp, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vorderwulbecke, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-599774
DOI: 10.1007/s10309-021-00444-x
Journal or Publication Title: Z. Epileptol.
Volume: 34
Number: 4
Page Range: S. 349 - 355
Date: 2021
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1610-0646
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STROKE; DEFINITION; VALIDATION; MODEL; RISKMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59977

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