Sujana, Chaterina ORCID: 0000-0002-0663-2557, Salomaa, Veikko ORCID: 0000-0001-7563-5324, Kee, Frank, Costanzo, Simona ORCID: 0000-0003-4569-1186, Soderberg, Stefan ORCID: 0000-0001-9225-1306, Jordan, Jens, Jousilahti, Pekka, Neville, Charlotte, Iacoviello, Licia ORCID: 0000-0003-0514-5885, Oskarsson, Viktor, Westermann, Dirk, Koenig, Wolfgang ORCID: 0000-0002-2064-9603, Kuulasmaa, Kari, Reinikainen, Jaakko, Blankenberg, Stefan, Zeller, Tanja, Herder, Christian, Mansmann, Ulrich, Peters, Annette ORCID: 0000-0001-6645-0985 and Thorand, Barbara (2021). Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium. Diabetes Care, 44 (11). S. 2527 - 2536. ALEXANDRIA: AMER DIABETES ASSOC. ISSN 1935-5548

Full text not available from this repository.

Abstract

OBJECTIVE Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD. RESEARCH DESIGN AND METHODS Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models. RESULTS Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95% CI] per 1-SD increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without CVD but not in individuals with CVD (0.81 [0.76; 0.86] vs. 1.04 [0.90; 1.19]; P multiplicative interaction = 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs. 0.81 [0.66; 0.99]; P multiplicative interaction = 0.236). CONCLUSIONS NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sujana, ChaterinaUNSPECIFIEDorcid.org/0000-0002-0663-2557UNSPECIFIED
Salomaa, VeikkoUNSPECIFIEDorcid.org/0000-0001-7563-5324UNSPECIFIED
Kee, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costanzo, SimonaUNSPECIFIEDorcid.org/0000-0003-4569-1186UNSPECIFIED
Soderberg, StefanUNSPECIFIEDorcid.org/0000-0001-9225-1306UNSPECIFIED
Jordan, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jousilahti, PekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neville, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacoviello, LiciaUNSPECIFIEDorcid.org/0000-0003-0514-5885UNSPECIFIED
Oskarsson, ViktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westermann, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDorcid.org/0000-0002-2064-9603UNSPECIFIED
Kuulasmaa, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinikainen, JaakkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blankenberg, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeller, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herder, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mansmann, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, AnnetteUNSPECIFIEDorcid.org/0000-0001-6645-0985UNSPECIFIED
Thorand, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603909
DOI: 10.2337/dc21-0811
Journal or Publication Title: Diabetes Care
Volume: 44
Number: 11
Page Range: S. 2527 - 2536
Date: 2021
Publisher: AMER DIABETES ASSOC
Place of Publication: ALEXANDRIA
ISSN: 1935-5548
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEART-FAILURE; PREDICTS; OBESITY; ADULTSMultiple languages
Endocrinology & MetabolismMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60390

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item