Kumsta, Caroline, Chang, Jessica T., Lee, Reina, Tan, Ee Phie, Yang, Yongzhi, Loureiro, Rute, Choy, Elizabeth H., Lim, Shaun H. Y., Saez, Isabel, Springhorn, Alexander, Hoppe, Thorsten ORCID: 0000-0002-4734-9352, Vilchez, David and Hansen, Malene (2019). The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorhabditis elegans that transcript levels of sqst-1/p62 increase upon a hormetic heat shock, suggesting a role of SQST-1/p62 in stress response and aging. Here, we find that sqst-1/p62 is required for hormetic benefits of heat shock, including longevity, improved neuronal proteostasis, and autophagy induction. Furthermore, overexpression of SQST-1/p62 is sufficient to induce autophagy in distinct tissues, extend lifespan, and improve the fitness of mutants with defects in proteostasis in an autophagy-dependent manner. Collectively, these findings illustrate that increased expression of a selective autophagy receptor is sufficient to induce autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/p62 in proteotoxic stress responses.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kumsta, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, Jessica T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, ReinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Ee PhieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, YongzhiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loureiro, RuteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choy, Elizabeth H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lim, Shaun H. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saez, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Springhorn, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoppe, ThorstenUNSPECIFIEDorcid.org/0000-0002-4734-9352UNSPECIFIED
Vilchez, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, MaleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-124559
DOI: 10.1038/s41467-019-13540-4
Journal or Publication Title: Nat. Commun.
Volume: 10
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INCLUSION-BODY FORMATION; LIFE-SPAN EXTENSION; CAENORHABDITIS-ELEGANS; MONITORING AUTOPHAGY; PROTEIN AGGREGATION; STRUCTURAL BASIS; P62; STRESS; GENES; ACCUMULATIONMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12455

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item