Gorges, Martin, Kunz, Martin S., Mueller, Hans-Peter, Liepelt-Scarfone, Inga, Storch, Alexander, Dodel, Richard, Hilker-Roggendorf, Ruediger, Berg, Daniela, Kalbe, Elke, Braak, Heiko, Del Tredici, Kelly ORCID: 0000-0002-9130-7838, Baudrexel, Simon, Huppertz, Hans-Juergen, Kassubek, Jan ORCID: 0000-0002-7106-9270, Mollenhauer, B., Schulz, J., Spottke, A., Storch, A. and Wittchen, H. -U. (2020). Longitudinal brain atrophy distribution in advanced Parkinson's disease: What makes the difference in cognitive status converters? Hum. Brain Mapp., 41 (6). S. 1416 - 1435. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

We investigated the brain atrophy distribution pattern and rate of regional atrophy change in Parkinson's disease (PD) in association with the cognitive status to identify the morphological characteristics of conversion to mild cognitive impairment (MCI) and dementia (PDD). T1-weighted longitudinal 3T MRI data (up to four follow-up assessments) from neuropsychologically well-characterized advanced PD patients (n = 172, 8.9 years disease duration) and healthy elderly controls (n = 85) enrolled in the LANDSCAPE study were longitudinally analyzed using a linear mixed effect model and atlas-based volumetry and cortical thickness measures. At baseline, PD patients presented with cerebral atrophy and cortical thinning including striatum, temporoparietal regions, and primary/premotor cortex. The atrophy was already observed in cognitively normal PD patients (PD-N) and was considerably more pronounced in cognitively impaired PD patients. Linear mixed effect modeling revealed almost similar rates of atrophy change in PD and controls. The group comparison at baseline between those PD-N whose cognitive performance remained stable (n = 42) and those PD-N patients who converted to MCI/PDD (converter cPD-N, n = 26) indicated suggested cortical thinning in the anterior cingulate cortex in cPD-N patients which was correlated with cognitive performance. Our results suggest that cortical brain atrophy has been already expanded in advanced PD patients without overt cognitive deficits while atrophy progression in late disease did not differ from normal aging regardless of the cognitive status. It appears that cortical atrophy begins early and progresses already in the initial disease stages emphasizing the need for therapeutic interventions already at disease onset.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gorges, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunz, Martin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker-Roggendorf, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braak, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Tredici, KellyUNSPECIFIEDorcid.org/0000-0002-9130-7838UNSPECIFIED
Baudrexel, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huppertz, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Mollenhauer, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, H. -U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-124903
DOI: 10.1002/hbm.24884
Journal or Publication Title: Hum. Brain Mapp.
Volume: 41
Number: 6
Page Range: S. 1416 - 1435
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0193
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CORTICAL THICKNESS; DIAGNOSTIC-CRITERIA; TASK-FORCE; DEMENTIA; IMPAIRMENT; BIOMARKERS; PATHOLOGY; RESERVEMultiple languages
Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12490

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