Hermanns, Thomas ORCID: 0000-0001-5350-7479 and Hofmann, Kay (2019). Bacterial DUBs: deubiquitination beyond the seven classes. Biochem. Soc. Trans., 47. S. 1857 - 1867. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752

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Abstract

Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-kappa B activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysosome, ubiquitination is also an important component of cell-autonomous immunity. Not surprisingly, several pathogenic bacteria encode deubiquitinases (DUBs) and use them as secreted effectors that prevent ubiquitination of bacterial components. A systematic overview of known bacterial DUBs, including their cleavage specificities and biological roles, suggests multiple independent acquisition events from host-encoded DUBs and other proteases. The widely used classification of DUBs into seven well-defined families should only be applied to eukaryotic DUBs, since several bacterial DUBs do not follow this classification.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hermanns, ThomasUNSPECIFIEDorcid.org/0000-0001-5350-7479UNSPECIFIED
Hofmann, KayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-125223
DOI: 10.1042/BST20190526
Journal or Publication Title: Biochem. Soc. Trans.
Volume: 47
Page Range: S. 1857 - 1867
Date: 2019
Publisher: PORTLAND PRESS LTD
Place of Publication: LONDON
ISSN: 1470-8752
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NF-KAPPA-B; EFFECTOR XOPD TARGETS; ALPHA UBIQUITINATION; AUTOPHAGY; YOPJ; TRANSCRIPTION; SPECIFICITY; SUPPRESSION; ACTIVATION; PHAGOSOMEMultiple languages
Biochemistry & Molecular BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12522

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