Universität zu Köln

Bleckwehl, Tore and Rada-Iglesias, Alvaro (2019). Transcriptional and epigenetic control of germline competence and specification. Curr. Opin. Cell Biol., 61. S. 1 - 9. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

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Abstract

In mammals, germline specification is induced during early embryogenesis when competent cells respond to extrinsic signals and form primordial germ cells (PGCs), the precursors of the gametes. The fusion of the two types of gametes, the egg and the sperm, gives rise to a new organism and closes the germline cycle. With the entry of the germline, the PGCs are separated from the soma and thus ensure the self-perpetuation of the species. Using the mouse as a model of mammalian embryogenesis, in this review we will focus on the transcriptional and epigenetic changes that regulate the initial steps of germline development, namely germline competence and PGC specification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bleckwehl, Tore UNSPECIFIED UNSPECIFIED UNSPECIFIED Rada-Iglesias, Alvaro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125836
DOI:	10.1016/j.ceb.2019.05.006
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	61
Page Range:	S. 1 - 9
Date:	2019
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL FATE; DNA METHYLATION; NAIVE PLURIPOTENCY; IN-VITRO; LINEAGE; TRANSITION; DYNAMICS; PROGRESSION; ACTIVATION; PRINCIPLES Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12583