Universität zu Köln

Bischof, Gerard N., Ewers, Michael, Franzmeier, Nicolai, Grothe, Michel J., Hoenig, Merle, Kocagoncu, Ece, Neitzel, Julia, Rowe, James B., Strafella, Antonio, Drzezga, Alexander and van Eimeren, Thilo (2019). Connectomics and molecular imaging in neurodegeneration. Eur. J. Nucl. Med. Mol. Imaging, 46 (13). S. 2819 - 2831. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Our understanding on human neurodegenerative disease was previously limited to clinical data and inferences about the underlying pathology based on histopathological examination. Animal models and in vitro experiments have provided evidence for a cell-autonomous and a non-cell-autonomous mechanism for the accumulation of neuropathology. Combining modern neuroimaging tools to identify distinct neural networks (connectomics) with target-specific positron emission tomography (PET) tracers is an emerging and vibrant field of research with the potential to examine the contributions of cell-autonomous and non-cell-autonomous mechanisms to the spread of pathology. The evidence provided here suggests that both cell-autonomous and non-cell-autonomous processes relate to the observed in vivo characteristics of protein pathology and neurodegeneration across the disease spectrum. We propose a synergistic model of cell-autonomous and non-cell-autonomous accounts that integrates the most critical factors (i.e., protein strain, susceptible cell feature and connectome) contributing to the development of neuronal dysfunction and in turn produces the observed clinical phenotypes. We believe that a timely and longitudinal pursuit of such research programs will greatly advance our understanding of the complex mechanisms driving human neurodegenerative diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewers, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Franzmeier, Nicolai UNSPECIFIED UNSPECIFIED UNSPECIFIED Grothe, Michel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenig, Merle UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocagoncu, Ece UNSPECIFIED UNSPECIFIED UNSPECIFIED Neitzel, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rowe, James B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Strafella, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125849
DOI:	10.1007/s00259-019-04394-5
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	46
Number:	13
Page Range:	S. 2819 - 2831
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; AMYLOID DEPOSITION; BASAL FOREBRAIN; REGIONAL EXPRESSION; PARKINSONS-DISEASE; CONNECTIVITY; ATROPHY; TAU; DOPAMINE; PATTERNS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12584