Universität zu Köln

Luescher, Sergio H., Nocciolino, Laura M., Pilot, Nicolas, Pisani, Leonardo, Ireland, Alex, Rittweger, Joern, Ferretti, Jose L., Cointry, Gustavo R. and Capozza, Ricardo F. (2019). Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls. Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure. Front. Endocrinol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-2392

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Abstract

The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower shape-index (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luescher, Sergio H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nocciolino, Laura M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilot, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pisani, Leonardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Ireland, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferretti, Jose L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cointry, Gustavo R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Capozza, Ricardo F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126998
DOI:	10.3389/fendo.2019.00833
Journal or Publication Title:	Front. Endocrinol.
Volume:	10
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-2392
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEX-DIFFERENCES; IN-VIVO; STRAIN; SIZE; PQCT; ADAPTATION; STRENGTH; GEOMETRY; EXERCISE; DENSITY Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12699