Park, Se Eun, Toy, Trevor, Espinoza, Ligia Maria Cruz, Panzner, Ursula, Mogeni, Ondari D., Im, Justin, Poudyal, Nimesh, Pak, Gi Deok, Seo, Hyeongwon, Chon, Yun, Schutt-Gerowitt, Heidi, Mogasale, Vittal ORCID: 0000-0003-0596-8072, Ramani, Enusa, Dey, Ayan ORCID: 0000-0002-0718-7336, Park, Ju Yeong, Kim, Jong-Hoon, Seo, Hye Jin, Jeon, Hyon Jin, Haselbeck, Andrea, Conway Roy, Keriann, MacWright, William, Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Osei, Isaac, Owusu, Michael, Rakotozandrindrainy, Raphael, Soura, Abdramane Bassiahi, Kabore, Leon Parfait, Teferi, Mekonnen, Okeke, Iruka N., Kehinde, Aderemi, Popoola, Oluwafemi, Jacobs, Jan, Metila, Octavie Lunguya, Meyer, Christian G., Crump, John A., Elias, Sean, Maclennan, Calman A., Parry, Christopher M., Baker, Stephen, Mintz, Eric D., Breiman, Robert F., Clemens, John D. and Marks, Florian (2019). The Severe Typhoid Fever in Africa Program: Study Design and Methodology to Assess Disease Severity, Host Immunity, and Carriage Associated With Invasive Salmonellosis. Clin. Infect. Dis., 69. S. S422 - 13. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Background. Invasive salmonellosis is a common community-acquired bacteremia in persons residing in sub-Saharan Africa. However, there is a paucity of data on severe typhoid fever and its associated acute and chronic host immune response and carriage. The Severe Typhoid Fever in Africa (SETA) program, a multicountry surveillance study, aimed to address these research gaps and contribute to the control and prevention of invasive salmonellosis. Methods. A prospective healthcare facility-based surveillance with active screening of enteric fever and clinically suspected severe typhoid fever with complications was performed using a standardized protocol across the study sites in Burkina Faso, the Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria. Defined inclusion criteria were used for screening of eligible patients for enrollment into the study. Enrolled patients with confirmed invasive salmonellosis by blood culture or patients with clinically suspected severe typhoid fever with perforation were eligible for clinical follow-up. Asymptomatic neighborhood controls and immediate household contacts of each case were enrolled as a comparison group to assess the level of Salmonella-specific antibodies and shedding patterns. Healthcare utilization surveys were performed to permit adjustment of incidence estimations. Postmortem questionnaires were conducted in medically underserved areas to assess death attributed to invasive Salmonella infections in selected sites. Results. Research data generated through SETA aimed to address scientific knowledge gaps concerning the severe typhoid fever and mortality, long-term host immune responses, and bacterial shedding and carriage associated with natural infection by invasive salmonellae. Conclusions. SETA supports public health policy on typhoid immunization strategy in Africa.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toy, TrevorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinoza, Ligia Maria CruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mogeni, Ondari D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Im, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poudyal, NimeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seo, HyeongwonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chon, YunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schutt-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mogasale, VittalUNSPECIFIEDorcid.org/0000-0003-0596-8072UNSPECIFIED
Ramani, EnusaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dey, AyanUNSPECIFIEDorcid.org/0000-0002-0718-7336UNSPECIFIED
Park, Ju YeongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Jong-HoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seo, Hye JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeon, Hyon JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haselbeck, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conway Roy, KeriannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacWright, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owusu-Dabo, EllisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osei, IsaacUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owusu, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rakotozandrindrainy, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soura, Abdramane BassiahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabore, Leon ParfaitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teferi, MekonnenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okeke, Iruka N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kehinde, AderemiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popoola, OluwafemiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobs, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metila, Octavie LunguyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crump, John A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elias, SeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maclennan, Calman A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parry, Christopher M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mintz, Eric D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breiman, Robert F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clemens, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-127557
DOI: 10.1093/cid/ciz715
Journal or Publication Title: Clin. Infect. Dis.
Volume: 69
Page Range: S. S422 - 13
Date: 2019
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DRUG-RESISTANCE; GLOBAL BURDEN; SURVEILLANCEMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12755

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