Universität zu Köln

Kauke, Martin, Safi, Ali-Farid, Stavrinou, Pantelis, Krischek, Boris, Goldbrunner, Roland and Timmer, Marco (2019). Does Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade? J. Craniofac. Surg., 30 (8). S. E799 - 5. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-3732

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Abstract

Objectives: The aim of the study was to investigate the association between meningioma volume and the occurrence of clinic-radiologic signs of tumor aggressiveness. For volumetric approximation, the authors evaluated the method of semiautomatic image segmentation at hand of high-resolution MRI-image sequences. Methods: ITK-SNAP was utilized for semiautomatic image segmentation of 58 gadolinium-contrast enhanced TI-weighted thin-slice MRI datasets for volumetric analysis. Furthermore, multi-modal imaging datasets (including T2, FLAIR, T1) were evaluated for radiological biomarkers of aggressiveness and growth potential. Thereby generated data was checked for association with retrospectively collected data points. Results: Location (P =0.001), clinical disease manifestation (P = 0.033), peritumoral edema (P = 0.038), tumor intrinsic cystic degeneration (P = 0.007), three-dimensional complexity (P = 0.022), and the presence of meningioma mass effect (P = 0.001) were statistically associated with higher tumor volumes. There was no association between higher tumor volumes and histopathological tumor grade. Conclusion: The size of a meningioma does not seem to reliably predict tumor grade. Growth potential seems to be influenced by tumor location. Higher tumor volumes were significantly associated with the occurrence of clinical symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kauke, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128477
DOI:	10.1097/SCS.0000000000005845
Journal or Publication Title:	J. Craniofac. Surg.
Volume:	30
Number:	8
Page Range:	S. E799 - 5
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-3732
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12847