Gravesande, K. Storm Van's, Calabrese, P., Blaschek, A., Rostasy, K., Huppke, P., Rothe, L., Mall, V, Kessler, J., Kalbe, E., Kraus, V, Dornfeld, E., Elpers, C., Lohmann, H., Weddige, A., Hagspiel, S., Kirschner, J., Brehm, M., Blank, C., Schubert, J., Schimmel, M., Pachee, S., Mohrbach, M., Karenfort, M., Kamp, G., Luecke, T., Neumann, H., Lutz, S., Gierse, A., Sievers, S., Schiffmann, H., de Soye, I, Trollmann, R., Candova, A., Rosner, M., Neu, A., Romer, G., Seidel, U., John, R., Hofmann, C., Kinder, S., Bertolatus, A., Scheidtmann, K., Lasogga, R., Leiz, S., Alber, M., Kranz, J., Bajer-Kornek, B., Seidl, R. and Novak, A. (2019). The Multiple Sclerosis Inventory of Cognition for Adolescents (MUSICADO): A brief screening instrument to assess cognitive dysfunction, fatigue and loss of health-related quality of life in pediatric-onset multiple sclerosis. Eur. J. Paediatr. Neurol., 23 (6). S. 792 - 801. OXFORD: ELSEVIER SCI LTD. ISSN 1532-2130

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Abstract

Objective: Screening for cognitive impairment (CI), fatigue and also Health-related quality of life (HRQoL) in patients with pediatric-onset multiple sclerosis (POMS) is of utmost importance in clinical practice. The aim of this study was to establish a new and validated pediatric screening tool MUSICADO that is easy to use and time economical. Methods: 106 patients with POMS aged 12-18 years and 210 healthy controls (HCs) stratified for age and education underwent neuropsychological testing including a screening test Multiple Sclerosis Inventory of Cognition for adults and 8 standardized cognitive tests and established scales to assess fatigue and HRQoL. Results: The phonemic verbal fluency task (RWT s-words), the Trail Making Test A (TMTA), and the Digit Span Forward discriminated significantly between patients and HCs (p = 0.000, respectively) and showed the highest proportion of test failure in patients 24.5%, 17.9%; 15.1%, respectively). Therefore, they were put together to form the cognitive part of the MUSICADO. After applying a scoring algorithm with balanced weighting of the subtests and age and education correction and a cut-off score for impairment, 35.8% of patients were categorized to be cognitively impaired (specificity: 88.6%). Fatigue was detected in 37.1% of the patients (specificity: 94.0%) and loss of HRQoL in 41.8% (specificity 95.7%) with the screening version, respectively. Conclusion: The MUSICADO is a newly designed brief and easy to use screening test to help to early identify CI, fatigue, and loss of HRQoL in patients with POMS as cut scores are provided for all three items. Further studies will have to show its usability in independent samples of patients with POMS. (C) 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gravesande, K. Storm Van'sUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calabrese, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blaschek, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rostasy, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huppke, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothe, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mall, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraus, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dornfeld, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elpers, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohmann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weddige, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagspiel, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirschner, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brehm, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schimmel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pachee, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohrbach, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karenfort, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamp, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luecke, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lutz, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gierse, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sievers, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiffmann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Soye, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trollmann, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candova, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neu, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofmann, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kinder, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolatus, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheidtmann, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasogga, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leiz, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alber, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bajer-Kornek, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidl, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-128841
DOI: 10.1016/j.ejpn.2019.08.006
Journal or Publication Title: Eur. J. Paediatr. Neurol.
Volume: 23
Number: 6
Page Range: S. 792 - 801
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1532-2130
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PSYCHOSOCIAL FEATURES; CHILDHOOD; RELIABILITY; CHILDREN; PEDSQL(TM)-4.0; IMPAIRMENT; VERSIONMultiple languages
Clinical Neurology; PediatricsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12884

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