Stelmes, Jean-Jacques, Gregoire, Vincent, Vander Poorten, Vincent, Golusinski, Wojciech, Szewczyk, Mateusz ORCID: 0000-0002-6834-5369, Jones, Terry, Ansarin, Mohssen, Broglie, Martina A., Giger, Roland, Klussmann, Jens Peter, Evans, Mererid, Bourhis, Jean ORCID: 0000-0001-5162-1171, Leemans, C. Rene, Spriano, Giuseppe, Dietz, Andreas, Hunter, Keith, Zimmermann, Frank, Tinhofer, Ingeborg, Patterson, Joanne M., Quaglini, Silvana, Govaerts, Anne-Sophie, Fortpied, Catherine and Simon, Christian (2019). Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the Best of Trial. Front. Oncol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 Best of trial, and highlight the potential of this study to help prioritizing either surgery- or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stelmes, Jean-JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gregoire, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vander Poorten, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golusinski, WojciechUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szewczyk, MateuszUNSPECIFIEDorcid.org/0000-0002-6834-5369UNSPECIFIED
Jones, TerryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansarin, MohssenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broglie, Martina A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giger, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klussmann, Jens PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, MereridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bourhis, JeanUNSPECIFIEDorcid.org/0000-0001-5162-1171UNSPECIFIED
Leemans, C. ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spriano, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietz, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmermann, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tinhofer, IngeborgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, Joanne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaglini, SilvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Govaerts, Anne-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fortpied, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-130570
DOI: 10.3389/fonc.2019.00999
Journal or Publication Title: Front. Oncol.
Volume: 9
Date: 2019
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2234-943X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSORAL ROBOTIC SURGERY; QUALITY-OF-LIFE; SQUAMOUS-CELL CARCINOMA; MODULATED RADIATION-THERAPY; NECK-CANCER; LONG-TERM; REDUCE DYSPHAGIA; ADVANCED HEAD; NRG ONCOLOGY; CHEMO-IMRTMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13057

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