Universität zu Köln

Sitnikov, Nikolay S., Malysheva, Yulia B., Fedorov, Alexey Yu. ORCID: 0000-0003-4889-8617 and Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 (2019). Design and Synthesis of New Protease-Triggered CO-Releasing Peptide-Metal-Complex Conjugates. Eur. J. Org. Chem., 2019 (40). S. 6830 - 6838. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0690

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Abstract

Aiming at the development of novel protease-triggered CO-releasing molecules (PT-CORMs) we designed a series of oxycyclohexadiene-Fe(CO)(3) complexes, which are connected through a self-immolative linker with a plasmin-specifying peptide unit. The challenging synthesis of these compounds was elaborated employing a combination of solid-phase peptide synthesis and solution chemical synthesis. Late-stage attachment of the organometallic unit and Pd-catalyzed cleavage of an alloc-protected lysine side chain afforded the target compounds in good yields and high purity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sitnikov, Nikolay S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Malysheva, Yulia B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorov, Alexey Yu. UNSPECIFIED orcid.org/0000-0003-4889-8617 UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130753
DOI:	10.1002/ejoc.201901206
Journal or Publication Title:	Eur. J. Org. Chem.
Volume:	2019
Number:	40
Page Range:	S. 6830 - 6838
Date:	2019
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1099-0690
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOLECULES ET-CORMS; CARBON-MONOXIDE; DRUG-DELIVERY; TRICARBONYL COMPLEXES; BIOLOGICAL EVALUATION; SELECTIVE ACTIVATION; PRODRUGS Multiple languages Chemistry, Organic Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13075