Universität zu Köln

Wilden, Sophia, Friis, Marina, Tuettenberg, Andrea, Staubach-Renz, Petra, Wegner, Joanna, Grabbe, Stephan and von Stebut, Esther . Combined treatment of hidradenitis suppurativa with intense pulsed light (IPL) and radiofrequency (RF). J. Dermatol. Treat.. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1471-1753

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Abstract

Background: Hidradenitis suppurativa is a chronic inflammatory disease with high burden. Treatment options are often unsatisfactory. We assessed the effect of a combination therapy of intense pulsed light (IPL) and radiofrequency (RF). Methods: The explorative study included 47 patients and was performed as a prospective, monocentric, randomized, three-arm parallel-group design trial with a prior 12?weeks observation period. Treatment arms were IPL and RF monotherapies or IPL?+?RF combination therapy. After 12?weeks, all patients received IPL?+?RF for additional 12?weeks (cross-over). Primary endpoint was the change in active lesion numbers, secondary endpoint the change in Dermatology Quality of Life Index (DLQI). Results: After 12?weeks, active lesion counts of the IPL?+?RF group decreased more than in the IPL group (p?=?.044); the decrease in DLQI was significantly higher in the IPL?+?RF and RF groups compared to IPL. Prolonged 24-week treatment with IPL?+?RF obtained better results as 12?weeks. Overall, disease burden after 24?weeks of treatment compared to disease fluctuation during the observation period was significantly lower (change in active lesions ?3.6, p?=?.001; in DLQI ?5.2, p?=?.003). Conclusions: IPL?+?RF treatment appears to represent a promising therapeutic option that leads to reduction of disease activity without severe side effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wilden, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Friis, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Tuettenberg, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Staubach-Renz, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegner, Joanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Grabbe, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130801
DOI:	10.1080/09546634.2019.1677842
Journal or Publication Title:	J. Dermatol. Treat.
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1471-1753
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONABLATIVE RADIOFREQUENCY; ACNE-VULGARIS; CLINDAMYCIN; COMBINATION; THERAPY; LASER Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13080