Universität zu Köln

Fuchs, Frieder ORCID: 0000-0001-7075-5378 and Hamprecht, Axel ORCID: 0000-0003-1449-5780 (2019). Susceptibility of carbapenemase-producing Enterobacterales (CPE) to nitroxoline. J. Antimicrob. Chemother., 74 (10). S. 2934 - 2938. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Background Infections caused by carbapenemase-producing Enterobacterales (CPE) constitute a major global health concern and are associated with increased morbidity and mortality. Nitroxoline is an old antibiotic, which has recently been re-launched for the treatment of uncomplicated urinary tract infection. Because of low resistance rates it could be an interesting option for treatment of MDR isolates, yet data on CPE susceptibility are scarce. Objectives To analyse the in vitro activity of nitroxoline against CPE. Methods MICs of nitroxoline were determined by agar dilution for a collection of well-characterized carbapenemase producers (n=105), producing OXA-48-like (n=36), VIM (n=21), IMI (n=9), IMP (n=6), NDM (n=22), KPC (n=11), OXA-58 (n=2) and GES (n=2). For comparison, MICs of ertapenem, imipenem and meropenem were determined by agar gradient diffusion. Results For all 105 isolates, the MIC50/90 of nitroxoline was 8/16mg/L. All Escherichia coli isolates (30/30, 100%) showed low MICs of 2-8mg/L and were susceptible to nitroxoline. MICs of 32mg/L were recorded for five isolates of VIM- and IMI-producing Enterobacter cloacae (n=3) and OXA- and VIM-producing Klebsiella pneumoniae (n=2). Conclusions Nitroxoline exhibited excellent in vitro activity against most isolates producing common and rare carbapenemases. If the current EUCAST susceptibility breakpoint of <= 16mg/L for E. coli in uncomplicated urinary tract infections was applied, 95.2% (100/105) of isolates would be classified as susceptible. Nitroxoline could therefore be an alternative oral option for treatment of uncomplicated urinary tract infections caused by CPE.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fuchs, Frieder UNSPECIFIED orcid.org/0000-0001-7075-5378 UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132350
DOI:	10.1093/jac/dkz275
Journal or Publication Title:	J. Antimicrob. Chemother.
Volume:	74
Number:	10
Page Range:	S. 2934 - 2938
Date:	2019
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2091
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language URINARY-TRACT-INFECTIONS; IN-VITRO; INHIBITION Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13235