Universität zu Köln

Safi, Ali-Farid, Grochau, Kathrin, Drebber, Uta, Schick, Volker, Thiele, Oliver ORCID: 0000-0001-5958-9583, Backhaus, Tim, Nickenig, Hans-Joachim, Zoeller, Joachim E. and Kreppel, Matthias (2019). A novel histopathological scoring system for patients with oral squamous cell carcinoma. Clin. Oral Investig., 23 (10). S. 3759 - 3766. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1436-3771

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Abstract

Objectives Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters. Materials and methods Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points. Results T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate. Conclusion Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Grochau, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Oliver UNSPECIFIED orcid.org/0000-0001-5958-9583 UNSPECIFIED Backhaus, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132430
DOI:	10.1007/s00784-019-02804-4
Journal or Publication Title:	Clin. Oral Investig.
Volume:	23
Number:	10
Page Range:	S. 3759 - 3766
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1436-3771
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE RATIO; LOCOREGIONAL RECURRENCE; PROGNOSTIC FACTORS; VESSEL INVASION; CANCER; MALIGNANCY; SURVIVAL; CAVITY; TONGUE; CLASSIFICATION Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13243