Imperadore, Pamela, Parazzoli, Dario, Oldani, Amanda, Duebbert, Michael, Bueschges, Ansgar and Fiorito, Graziano (2019). From injury to full repair: nerve regeneration and functional recovery in the common octopus, Octopus vulgaris. J. Exp. Biol., 222 (19). CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9145

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Abstract

Spontaneous nerve regeneration in cephalopod molluscs occurs in a relative short time after injury, achieving functional recovery of lost capacity. In particular, transection of the pallial nerve in the common octopus (Octopus vulgaris) determines the loss and subsequent restoration of two functions fundamental for survival, i.e. breathing and skin patterning, the latter involved in communication between animals and concealment. The phenomena occurring after lesion have been investigated in a series of previous studies, but a complete analysis of the changes taking place at the level of the axons and the effects on the animals' appearance during the whole regenerative process is still missing. Our goal was to determine the course of events following injury, from impairment to full recovery. Through imaging of the traced damaged nerves, we were able to characterize the pathways followed by fibres during regeneration and end-target re-innervation, while electrophysiology and behavioural observations highlighted the regaining of functional connections between the central brain and periphery, using the contralateral nerve in the same animal as an internal control. The final architecture of a fully regenerated pallial nerve does not exactly mirror the original structure; however, functionality returns to match the phenotype of an intact octopus with no observable impact on the behaviour of the animal. Our findings provide new important scenarios for the study of regeneration in cephalopods and highlight the octopus pallial nerve as a valuable 'model' among invertebrates.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Imperadore, PamelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parazzoli, DarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oldani, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duebbert, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bueschges, AnsgarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiorito, GrazianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-132474
DOI: 10.1242/jeb.209965
Journal or Publication Title: J. Exp. Biol.
Volume: 222
Number: 19
Date: 2019
Publisher: COMPANY BIOLOGISTS LTD
Place of Publication: CAMBRIDGE
ISSN: 1477-9145
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CEPHALOPODS; SYSTEMMultiple languages
BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13247

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