Universität zu Köln

Riedemann, Sophie, Sutor, Bernd, Bergami, Matteo ORCID: 0000-0001-5525-5025 and Riedemann, Therese (2019). Gad1-promotor-driven GFP expression in non-GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line. J. Comp. Neurol., 527 (14). S. 2215 - 2233. HOBOKEN: WILEY. ISSN 1096-9861

Full text not available from this repository.

Abstract

Transgenic animals have become a widely used model to identify and study specific cell types in whole organs. Promotor-driven reporter gene labeling of the cells under investigation has promoted experimental efficacy to a large degree. However, rigorous assessment of transgene expression specificity in these animal models is highly recommended to validate cellular identity and to isolate potentially mislabeled cell populations. Here, we report on one such mislabeled neuron population in a widely used transgenic mouse line in which GABAergic somatostatin-expressing interneurons (SOMpos INs) are labeled by eGFP (so-called GIN mouse, FVB-Tg(GadGFP)45704Swn/J). These neurons represent a subpopulation of all SOMpos INs. However, we report here on GFP labeling of non-GABAergic neurons in the nucleus endopiriformis of this mouse line.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Riedemann, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Sutor, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED orcid.org/0000-0001-5525-5025 UNSPECIFIED Riedemann, Therese UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133462
DOI:	10.1002/cne.24673
Journal or Publication Title:	J. Comp. Neurol.
Volume:	527
Number:	14
Page Range:	S. 2215 - 2233
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-9861
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM-BINDING PROTEINS; PIRIFORM CORTEX; CINGULATE CORTEX; CLAUSTRUM; RAT; INTERNEURONS; SOMATOSTATIN; CONNECTIONS; ORGANIZATION; SUBTYPES Multiple languages Neurosciences; Zoology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13346