Universität zu Köln

Cui, Rongfeng ORCID: 0000-0002-8146-6958, Medeiros, Tania, Willemsen, David, Iasi, Leonardo N. M., Collier, Glen E., Graef, Martin, Reichard, Martin ORCID: 0000-0002-9306-0074 and Valenzano, Dario Riccardo (2019). Relaxed Selection Limits Lifespan by Increasing Mutation Load. Cell, 178 (2). S. 385 - 420. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

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Abstract

To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cui, Rongfeng UNSPECIFIED orcid.org/0000-0002-8146-6958 UNSPECIFIED Medeiros, Tania UNSPECIFIED UNSPECIFIED UNSPECIFIED Willemsen, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Iasi, Leonardo N. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Collier, Glen E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graef, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichard, Martin UNSPECIFIED orcid.org/0000-0002-9306-0074 UNSPECIFIED Valenzano, Dario Riccardo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135208
DOI:	10.1016/j.cell.2019.06.004
Journal or Publication Title:	Cell
Volume:	178
Number:	2
Page Range:	S. 385 - 420
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4172
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DNA-POLYMERASE GAMMA; MULTIPLE SEQUENCE ALIGNMENT; EVOLUTIONARY ADAPTATION; PHYLOGENETIC ANALYSIS; POPULATION HISTORY; PROVIDES INSIGHTS; READ ALIGNMENT; GENOME; PROTEIN; TOOL Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13520