Universität zu Köln

Riedel, Philipp, Heil, Matthias, Bender, Stephan, Dippel, Gabriel, Korb, Franziska M., Smolka, Michael N. and Marxen, Michael ORCID: 0000-0001-8870-0041 . Modulating functional connectivity between medial frontopolar cortex and amygdala by inhibitory and excitatory transcranial magnetic stimulation. Hum. Brain Mapp.. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

The prefrontal-limbic network in the human brain plays a major role in social cognition, especially cognitive control of emotion. The medial frontopolar cortex (mFP; Brodmann Area 10) and the amygdala are part of this network and display correlated neuronal activity in time, as measured by functional magnetic resonance imaging (fMRI). This functional connectivity is dynamic, sensitive to training, and affected in mental disorders. However, the effects of neurostimulation on functional connectivity within this network have not yet been systematically investigated. Here, we investigate the effects of both low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) to the right mFP on functional connectivity between mFP and amygdala, as measured with resting state fMRI (rsfMRI). Three groups of healthy participants received either low-frequency rTMS (1 Hz; N = 18), sham TMS (1 Hz, subthreshold; N = 18) or high-frequency rTMS (20 Hz; N = 19). rsfMRI was acquired before and after (separate days). We hypothesized a modulation of functional connectivity in opposite directions compared to sham TMS through adjustment of the stimulation frequency. Groups differed in functional connectivity between mFP and amygdala after stimulation compared to before stimulation (low-frequency: decrease, high-frequency: increase). Motion or induced changes in neuronal activity were excluded as confounders. Results show that rTMS is effective for increasing and decreasing functional coherence between prefrontal and limbic regions. This finding is relevant for social and affective neuroscience as well as novel treatment approaches in psychiatry.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Riedel, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Heil, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dippel, Gabriel UNSPECIFIED UNSPECIFIED UNSPECIFIED Korb, Franziska M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smolka, Michael N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marxen, Michael UNSPECIFIED orcid.org/0000-0001-8870-0041 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135543
DOI:	10.1002/hbm.24703
Journal or Publication Title:	Hum. Brain Mapp.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTROMEDIAL PREFRONTAL CORTEX; POSITRON-EMISSION-TOMOGRAPHY; THETA BURST STIMULATION; CORTICAL EXCITABILITY; DOPAMINE RELEASE; SOCIAL COGNITION; FRONTAL-CORTEX; RTMS; BRAIN; DEPRESSION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13554