Universität zu Köln

Osae, Eugene A., Steven, Philipp, Redfern, Rachel, Hanlon, Samuel, Smith, C. Wayne, Rumbaut, Rolando E. and Burns, Alan R. (2019). Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model. Int. J. Mol. Sci., 20 (14). BASEL: MDPI. ISSN 1422-0067

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Abstract

Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein levels) can initiate the development of MGD. However, conclusive evidence is lacking, and an experimental approach using a suitable model is necessary to interrogate the relationship between dyslipidemia and MGD. This systematic review discusses current knowledge on the associations between dyslipidemia and MGD. We briefly introduce a diet-induced obesity model where mice develop dyslipidemia, which can serve as a potential tool for investigating the effects of dyslipidemia on the meibomian gland. Finally, the utility of lipidomics to examine the link between dyslipidemia and MGD is considered.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Osae, Eugene A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Redfern, Rachel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanlon, Samuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, C. Wayne UNSPECIFIED UNSPECIFIED UNSPECIFIED Rumbaut, Rolando E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burns, Alan R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135641
DOI:	10.3390/ijms20143505
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	14
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DENSITY-LIPOPROTEIN CHOLESTEROL; HUMAN MEIBUM; INTERNATIONAL WORKSHOP; TEAR FILM; OCULAR SURFACE; METABOLIC SYNDROME; RISK; AGE; SUBCOMMITTEE; ASSOCIATION Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13564