Universität zu Köln

Korniy, Natalia, Samatova, Ekaterina, Anokhina, Maria M., Peske, Frank and Rodnina, Marina V. (2019). Mechanisms and biomedical implications of-1 programmed ribosome frameshifting on viral and bacterial mRNAs. FEBS Lett., 593 (13). S. 1468 - 1483. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

Some proteins are expressed as a result of a ribosome frameshifting event that is facilitated by a slippery site and downstream secondary structure elements in the mRNA. This review summarizes recent progress in understanding mechanisms of -1 frameshifting in several viral genes, including IBV 1a/1b, HIV-1 gag-pol, and SFV 6K, and in Escherichia coli dnaX. The exact frameshifting route depends on the availability of aminoacyl-tRNAs: the ribosome normally slips into the -1-frame during tRNA translocation, but can also frameshift during decoding at condition when aminoacyl-tRNA is in limited supply. Different frameshifting routes and additional slippery sites allow viruses to maintain a constant production of their key proteins. The emerging idea that tRNA pools are important for frameshifting provides new direction for developing antiviral therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Korniy, Natalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Samatova, Ekaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED Anokhina, Maria M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peske, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodnina, Marina V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-136043
DOI:	10.1002/1873-3468.13478
Journal or Publication Title:	FEBS Lett.
Volume:	593
Number:	13
Page Range:	S. 1468 - 1483
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SITE TRANSFER-RNA; STEM-LOOP; ESCHERICHIA-COLI; CODON-USAGE; PROTEASE INHIBITORS; STRUCTURAL BASIS; CLEAVAGE SITES; HIV-1 PROTEASE; GAMMA-SUBUNIT; G-QUADRUPLEX Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13604