Universität zu Köln

Ignarski, Michael ORCID: 0000-0001-6057-7694, Islam, Rashidul and Mueller, Roman-Ulrich (2019). Long Non-Coding RNAs in Kidney Disease. Int. J. Mol. Sci., 20 (13). BASEL: MDPI. ISSN 1422-0067

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Abstract

Non-coding RNA species contribute more than 90% of all transcripts and have gained increasing attention in the last decade. One of the most recent members of this group are long non-coding RNAs (lncRNAs) which are characterized by a length of more than 200 nucleotides and a lack of coding potential. However, in contrast to this simple definition, lncRNAs are heterogenous regarding their molecular function-including the modulation of small RNA and protein function, guidance of epigenetic modifications and a role as enhancer RNAs. Furthermore, they show a highly tissue-specific expression pattern. These aspects already point towards an important role in cellular biology and imply lncRNAs as players in development, health and disease. This view has been confirmed by numerous publications from different fields in the last years and has raised the question as to whether lncRNAs may be future therapeutic targets in human disease. Here, we provide a concise overview of the current knowledge on lncRNAs in both glomerular and tubulointerstitial kidney disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ignarski, Michael UNSPECIFIED orcid.org/0000-0001-6057-7694 UNSPECIFIED Islam, Rashidul UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-136055
DOI:	10.3390/ijms20133276
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	13
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACELLULAR-MATRIX ACCUMULATION; ISCHEMIA-REPERFUSION INJURY; STAGE RENAL-DISEASE; DIABETIC-NEPHROPATHY; PODOCYTE INJURY; POTENTIAL ROLE; KEY MOLECULE; MALAT1; PROLIFERATION; FIBROSIS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13605