Schennach, Rebecca, Obermeier, Michael, Spellmann, Ilja, Seemueller, Florian, Musil, Richard ORCID: 0000-0002-0792-8413, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoetter, Joachim, Heuser, Isabella, Bauer, Michael, Adli, Mazda, Zeiler, Joachim, Bender, Wolfram, Kronmueller, Klaus-Thomas, Ising, Marcus, Brieger, Peter, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan, Gastpar, Markus, Moeller, Hans-Juergen and Riedel, Michael (2019). Remission in schizophrenia - What are we measuring? Comparing the consensus remission criteria to a CGI-based definition of remission and to remission in major depression. Schizophr. Res., 209. S. 185 - 193. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Background: Despite being recommended for use in clinical trials, the consensus remission criteria were found to leave patients with persisting symptoms, relevant areas of functional impairment and a decreased sense of wellbeing. Therefore, to evaluate the appropriateness of the schizophrenia consensus criteria, a definition of remission based on the Clinical Global Impression Scale (CGI) was developed and remitter subgroups were compared. Methods: 239 patients with a schizophrenia spectrum disorder were evaluated regarding their remission status after inpatient treatment. Remission in schizophrenia was defined according to the symptom-severity component of the consensus criteria by Andreasen et al. and a CGI based definition was calculated using sensitivity and specificity using receiver operating curves (asymptomatic remitter). Both remitter groups (schizophrenia consensus versus asymptomatic remitters) were compared regarding different clinical variables at discharge as well as the likelihood to relapse within a 1-year follow-up period. Both schizophrenia remitter subgroups were compared to remitters in major depression as a reference value. Results: Following the consensus criteria, 63% of the schizophrenia patients were in remission compared to only 18% following the asymptomatic criterion. The schizophrenia consensus remitters were less likely to be concurrent treatment responders (p < 0.0001), had a significantly greater illness severity (p < 0.0001) and less functioning (p = 0.0358) as well as a significantly greater risk to relapse (p = 0.0174) compared to the schizophrenia asymptomatic remitters as well as the depressed remitters. Conclusion: It should be critically re-evaluated if the currently proposed consensus criteria are adequate to measure what is traditionally understood to be remission. (C) 2019 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schennach, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermeier, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spellmann, IljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seemueller, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musil, RichardUNSPECIFIEDorcid.org/0000-0002-0792-8413UNSPECIFIED
Jaeger, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmauss, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laux, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, HerbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naber, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Lutz G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuser, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adli, MazdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeiler, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bender, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronmueller, Klaus-ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ising, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brieger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemke, Matthias R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruether, EckartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingberg, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gastpar, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-136107
DOI: 10.1016/j.schres.2019.04.022
Journal or Publication Title: Schizophr. Res.
Volume: 209
Page Range: S. 185 - 193
Date: 2019
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2509
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOLOGICAL-PSYCHIATRY WFSBP; SYMPTOMATIC REMISSION; WORLD-FEDERATION; RECOVERY; VALIDITY; SCALE; ARIPIPRAZOLE; OUTPATIENTS; RISPERIDONE; PREDICTORSMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13610

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