Ihle, Peter, Krueger, Katrin, Schubert, Ingrid, Griese-Mammen, Nina, Parrau, Natalie, Laufs, Ulrich and Schulz, Martin ORCID: 0000-0002-5876-7322 (2019). Comparison of Different Strategies to Measure Medication Adherence via Claims Data in Patients With Chronic Heart Failure. Clin. Pharmacol. Ther., 106 (1). S. 211 - 219. HOBOKEN: WILEY. ISSN 1532-6535

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Abstract

Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of days covered (PDC) utilizing claims data from 2010 to 2015. We aimed to compare different parameters' influence on the PDC of elderly CHF patients exemplifying a complex chronic disease. Investigated parameters were the assumed prescribed daily dose (PDD), stockpiling, and periods of hospital stay. Thereby, we investigated a new approach using the PDD assigned to different percentiles. The different dose assumptions had the biggest influence on the PDC, with variations from 41.9% to 83.7%. Stockpiling and hospital stays increased the values slightly. These results queries that a reliable PDC can be calculated with an assumed PDD. Hence, results based on an assumed PDD have to be interpreted carefully and should be presented with sensitivity analyses to show the PDC's possible range.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ihle, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert, IngridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griese-Mammen, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parrau, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laufs, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, MartinUNSPECIFIEDorcid.org/0000-0002-5876-7322UNSPECIFIED
URN: urn:nbn:de:hbz:38-136337
DOI: 10.1002/cpt.1378
Journal or Publication Title: Clin. Pharmacol. Ther.
Volume: 106
Number: 1
Page Range: S. 211 - 219
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1532-6535
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIHYPERTENSIVE DRUG-THERAPY; STATIN THERAPY; PERSISTENCE; HOSPITALIZATION; NONADHERENCE; IMPACT; RISK; BENEFICIARIES; STANDARD; PROPOSALMultiple languages
Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13633

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