Universität zu Köln

Kern, Lara, Mittenbuehler, Melanie J., Vesting, Anna Juliane, Ostermann, Anna Lena, Wunderlich, Claudia Maria and Wunderlich, F. Thomas (2019). Obesity-Induced TNF alpha and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers, 11 (1). BASEL: MDPI. ISSN 2072-6694

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Abstract

Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNF alpha and IL-6 signaling in hepatocellular carcinoma and colorectal cancers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kern, Lara UNSPECIFIED UNSPECIFIED UNSPECIFIED Mittenbuehler, Melanie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vesting, Anna Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostermann, Anna Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, Claudia Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, F. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139913
DOI:	10.3390/cancers11010024
Journal or Publication Title:	Cancers
Volume:	11
Number:	1
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; HIGH-FAT-DIET; NECROSIS-FACTOR-ALPHA; INSULIN-RECEPTOR SUBSTRATE-1; INTESTINAL EPITHELIAL-CELLS; TYROSINE KINASE-ACTIVITY; MICE LACKING SUPPRESSOR; DEXTRAN SULFATE SODIUM; DSS-INDUCED COLITIS; BODY-MASS INDEX Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13991