Universität zu Köln

Vogt, Julia ORCID: 0000-0001-9190-3931, Wagener, Rabea, Montesinos-Rongen, Manuel, Ammerpohl, Ole, Paulus, Werner, Deckert, Martina and Siebert, Reiner (2019). Array-based profiling of the lymphoma cell DNA methylome does not unequivocally distinguish primary lymphomas of the central nervous system from non-CNS diffuse large B-cell lymphomas. Gene Chromosomes Cancer, 58 (1). S. 66 - 70. HOBOKEN: WILEY. ISSN 1098-2264

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Abstract

Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). We here performed array-based DNA methylation analyses of 26 PCNSL and 78 DLBCL and validated our findings in an independent dataset. We identified 2847 CpGs differentially methylated between PCNSL and non-CNS-DLBCL. Neither a supervised analysis using these CpGs nor application of 3 CpG classifiers selected for class separation unambiguously separated PCNSL from non-CNS-DLBCL. Remarkably, 6/78 non-CNS-DLBCL consistently segregated with PCNSL, which displayed molecular features typical for PCNSL. Our findings suggest that a subset of non-CNS-DLBCL exists which molecularly resembles PCNSL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vogt, Julia UNSPECIFIED orcid.org/0000-0001-9190-3931 UNSPECIFIED Wagener, Rabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Montesinos-Rongen, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ammerpohl, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulus, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebert, Reiner UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140749
DOI:	10.1002/gcc.22687
Journal or Publication Title:	Gene Chromosomes Cancer
Volume:	58
Number:	1
Page Range:	S. 66 - 70
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1098-2264
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METHYLATION; EXPRESSION; ABERRATIONS; TESTIS Multiple languages Oncology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14074